Ustekinumab, an IL-12/23 inhibitor, is an important agent in treatment of inflammatory bowel disease and psoriasis.Clinical trials have not demonstrated Snake Inspection Camera significantly increased infection risk with ustekinumab.We report a case of disseminated histoplasmosis in the setting of ustekinumab and methotrexate following a hike in the Catskill Mountains, a region not commonly associated with Histoplasma encapsulatum.To our knowledge, this is the Toys first reported case of newly acquired histoplasmosis complicating treatment with ustekinumab.